前往化源商城
入驻化源商城

N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲

更新时间:2024-01-02 23:18:02

N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲结构式
N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲结构式
品牌特惠专场
常用名 N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲 英文名 ABT-102
CAS号 808756-71-0 分子量 348.44
密度 1.24 g/cm3 沸点 529.5ºC at 760 mmHg
分子式 C21H24N4O 熔点 N/A
MSDS N/A 闪点 274.1ºC

 用途


ABT-102 是一种有效且高度选择性的 Vanilloid Receptor (TRPV1) 受体拮抗剂。ABT-102 有效且可逆地增加热痛阈值并减少阈上口腔/皮肤热痛。ABT-102 可减少炎症、骨癌、术后和骨关节炎疼痛模型中动物的伤害性反应。

 N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲名称

中文名 N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲
英文名 1-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-3-(1H-indazol-4-yl)urea
中文别名 N-(5-叔丁基茚满-1-基)-N'-(1H-吲唑-4-基)脲
英文别名 更多

 N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲生物活性

描述 ABT-102 是一种有效且高度选择性的 Vanilloid Receptor (TRPV1) 受体拮抗剂。ABT-102 有效且可逆地增加热痛阈值并减少阈上口腔/皮肤热痛。ABT-102 可减少炎症、骨癌、术后和骨关节炎疼痛模型中动物的伤害性反应。
相关类别
靶点

TRPV1

参考文献

[1]. Lukin K, et al. Development of a Large Scale Asymmetric Synthesis of Vanilloid Receptor (TRPV1) Antagonist ABT-102. Organic Process Research & Development, 2007, 11(3):578-584.

[2]. Rowbotham MC, et al. Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial. Pain. 2011 May;152(5):1192-1200.  

 N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲物理化学性质

密度 1.24 g/cm3
沸点 529.5ºC at 760 mmHg
分子式 C21H24N4O
分子量 348.44
闪点 274.1ºC
精确质量 348.19500
PSA 69.81000
LogP 5.13330
储存条件 2-8°C

 N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲合成线路

~%

N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲结构式

N-(5-叔丁基茚满-1-基)...

808756-71-0

文献:Lukin, Kirill A.; Hsu, Margaret Chi-Ping; Fernando, Dilinie P.; Kotecki, Brian J.; Leanna, Marvin R. Patent: US2007/244178 A1, 2007 ; Location in patent: Page/Page column 14 ;

~%

N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲结构式

N-(5-叔丁基茚满-1-基)...

808756-71-0

文献:Gomtsyan, Arthur; Bayburt, Erol K.; Schmidt, Robert G.; Surowy, Carol S.; Honore, Prisca; Marsh, Kennan C.; Hannick, Steven M.; McDonald, Heath A.; Wetter, Jill M.; Sullivan, James P.; Jarvis, Michael F.; Faltynek, Connie R.; Lee, Chih-Hung Journal of Medicinal Chemistry, 2008 , vol. 51, # 3 p. 392 - 395

~%

N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲结构式

N-(5-叔丁基茚满-1-基)...

808756-71-0

文献:Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatramani; Leanna Organic Process Research and Development, 2007 , vol. 11, # 3 p. 578 - 584

~%

N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲结构式

N-(5-叔丁基茚满-1-基)...

808756-71-0

文献:Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatramani; Leanna Organic Process Research and Development, 2007 , vol. 11, # 3 p. 578 - 584

~%

N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲结构式

N-(5-叔丁基茚满-1-基)...

808756-71-0

文献:Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatramani; Leanna Organic Process Research and Development, 2007 , vol. 11, # 3 p. 578 - 584

~%

N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲结构式

N-(5-叔丁基茚满-1-基)...

808756-71-0

文献:Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatramani; Leanna Organic Process Research and Development, 2007 , vol. 11, # 3 p. 578 - 584

~%

N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲结构式

N-(5-叔丁基茚满-1-基)...

808756-71-0

文献:Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatramani; Leanna Organic Process Research and Development, 2007 , vol. 11, # 3 p. 578 - 584

 N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲上下游产品

N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲上游产品  6

N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲下游产品  0

 N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲英文别名

N-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea
(R)-1-(5-tert-butylindan-1-yl)-3-(1H-indazol-4-yl)
ABT-102
品牌现货直购
推荐供应商:


查看所有供应商和价格请点击:

N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲生产厂家

N-(5-叔丁基茚满-1-基)-N-(1H-吲唑-4-基)脲价格