Tetrahedron

One-pot synthesis of novel (2-oxo-1, 2-dihydropyridin-3-yl)-1, 3, 5-triazine derivatives from methyl 2-(N-triphenylphosphoranylidene) aminonicotinate, aryl isocyanates …

T Okawa, N Osakada, S Eguchi, A Kakehi

文献索引：Okawa, Tomohiro; Osakada, Naoto; Eguchi, Shoji; Kakehi, Akikazu Tetrahedron, 1997 , vol. 53, # 47 p. 16061 - 16082

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被引用次数: 19

摘要

(2-Oxo-1, 2-dihydropyridin-3-yl)-1, 3, 5-triazine derivatives 10 were obtained unexpectedly, in stead of pyrido [2, 3-d] pyrimidine derivatives, by the intermolecular aza-Wittig reaction of methyl 2-(N-triphenylphosphoranylidene) aminonicotinate 3 with aryl isocyanates followed by attempted heterocyclization by use of prim-amines. A novel sequential aza- Wittig/cycloaddition/ring-transformation mechanism for the formation of 10 has been ...