Pyrimidinones. 3. N-substituted 6-phenylpyrimidinones and pyrimidinediones with diuretic/hypotensive and antiinflammatory activity

HI Skulnick, JH Ludens, MG Wendling…

文献索引：Skulnick; Ludens; Wendling; Glenn; Rohloff; Smith; Wierenga Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1499 - 1504

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被引用次数: 53

摘要

In an extensive analysis of the antiviral and interferon-induction structureactivity relationship of 6-arylpyrimidinones we found that modifications at positions 1-4 of the pyrimidine ring resulted in a loss of However, we uncovered interesting hypotensive and antiinflammatory activity with a series of N-substituted analogues, the results of which we report herein.