Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4, 6-Dehydratase

…, YJ Kim, S Caille, M Achmatowicz, O Thiel…

文献索引：Thiel, Oliver R.; Achmatowicz, Michal M. Organic Syntheses, 2013 , vol. 90, p. 287 - 300

被引用次数: 2

摘要

The efficacy of therapeutic antibodies that induce antibody-dependent cellular cytotoxicity can be improved by reduced fucosylation. Consequently, fucosylation is a critical product attribute of monoclonal antibodies produced as protein therapeutics. Small molecule

~93%

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~99%

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~76%

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~79%

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