Thromboxane A2 synthase inhibitors. 5-(3-Pyridylmethyl) benzofuran-2-carboxylic acids

…, JW Aiken, NJ Crittenden, RR Gorman

文献索引：Johnson; Nidy; Aiken; Crittenden; Gorman Journal of medicinal chemistry, 1986 , vol. 29, # 8 p. 1461 - 1468

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被引用次数: 37

摘要

The synthesis and screening of a series of 5-(3-pyridylmethyl) benzofuran-2-carboxylc acids as selective thromboxane A2 (TxA,) synthase inhibitors is outlined. The ability of these compounds to inhibit TxA2 biosynthesis was assayed using microsomal enzyme from human platelets. Substitution of the benzofuran ring caused small changes in potency; modification of the carboxylic acid group caused modest reductions in potency, and ...