Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors

…, M Fortunato, L Gowers, AF Haughan, LA James…

文献索引：Alam, Mahbub; Beevers, Rebekah E.; Ceska, Tom; Davenport, Richard J.; Dickson, Karen M.; Fortunato, Mara; Gowers, Lewis; Haughan, Alan F.; James, Lynwen A.; Jones, Mark W.; Kinsella, Natasha; Lowe, Christopher; Meissner, Johannes W.G.; Nicolas, Anne-Lise; Perry, Benjamin G.; Phillips, David J.; Pitt, William R.; Platt, Adam; Ratcliffe, Andrew J.; Sharpe, Andrew; Tait, Laura J. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 12 p. 3463 - 3467

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被引用次数: 44

摘要

The development of a series of novel aminopyrimidines as inhibitors of c-Jun N-terminal kinases is described. The synthesis, in vitro inhibitory values for JNK1, JNK2 and CDK2, and the in vitro inhibitory value for a c-Jun cellular assay are discussed. ... A series of novel aminopyrimidines is reported which exhibits JNK1 and JNK2 inhibitory activity. ... Inflammation is a key area of research for many pharmaceutical companies. Patients suffering from inflammatory ...