Imidazo [1, 2-a] pyridines. Part 2: SAR and optimisation of a potent and selective class of cyclin-dependent kinase inhibitors

…, JD Culshaw, S Green, SE Oakes, AP Thomas

文献索引：Byth, Kate F.; Culshaw, Janet D.; Green, Stephen; Oakes, Sandra E.; Thomas, Andrew P. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2245 - 2248

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被引用次数: 94

摘要

Exploration of SAR and optimisation of the imidazo [1, 2-a] pyridine CDK inhibitors has lead to the discovery of novel, potent and selective inhibitors of the cyclin-dependent kinase CDK2. Understanding of SAR has identified positions of substitution, which allow modification of physical properties and offer the potential for in vivo optimisation.