Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Stereoselective preparation of the 3-hydroxy metabolites of tibolone is easily accomplished by diastereoselective Candida antarctica lipase B-catalyzed transformations of 3α- and 3β-alcohols or acetates mixtures in organic solvents, in suitable amounts for biological studies. ... Tibolone 1 is a synthetic ...