Bolaamphiphiles promote phospholipid translocation across vesicle membranes

CC Forbes, KM DiVittorio, BD Smith

文献索引：Forbes, Christopher C.; DiVittorio, Kristy M.; Smith, Bradley D. Journal of the American Chemical Society, 2006 , vol. 128, # 28 p. 9211 - 9218

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被引用次数: 32

摘要

A series of membrane-spanning bolaamphiphiles (molecules with two hydrophilic end groups connected by a hydrophobic linker) were prepared by a modular synthetic method and evaluated for their abilities to affect the dynamics of a surrounding bilayer membrane. The goal was to determine if the bolaamphiphiles promote the translocation of phospholipids across vesicle membranes. The bolaamphiphiles were incorporated at low ...