Synthesis of dicyanopyridines

E Roblou, I Sasaki, F Pezet, H Aït??Haddou…

文献索引：Roblou, Emmanuel; Sasaki, Isabelle; Pezet, Frederic; Ait-Haddou, Hassan; Vincendeau, Sandrine Synthetic Communications, 2004 , vol. 34, # 20 p. 3743 - 3749

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被引用次数: 3

摘要

View all references Preferential functionalization on the α positions can be achieved by introducing a benzylidene group. During the course of the reaction, the nitrogen atom of the pyridine ring favors the reactivity on the α methyl groups leading to 3 as the major product in the presence of the tribenzylidene derivative (R = CH˭CHPh in Sch. 1) which is difficult to separate from 3. After two successive chromatographies on silica gel, compound 3 was finally obtained ...