Lehualides E− K, Cytotoxic Metabolites from the Tongan Marine Sponge Plakortis sp.

…, JH Miller, DS Bellows, PT Northcote

文献索引：Barber, Jacqueline M.; Quek, Natelle C. H.; Leahy, Dora C.; Miller, John H.; Bellows, David S.; Northcote, Peter T. Journal of Natural Products, 2011 , vol. 74, # 4 p. 809 - 815

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被引用次数: 8

摘要

Spectroscopy-guided chemical analysis of a marine sponge from the genus Plakortis, collected in Tonga, yielded seven new metabolites of polyketide origin, lehualides E− K (5− 11), four of which incorporate various sulfur functionalities. The structures of compounds 5− 11 were elucidated by interpretation of spectroscopic data and spectral comparison with model compounds. The biological activities of compounds 6− 9 were investigated against ...