Regioselective synthesis of natural and unnatural (Z)-3-(1-alkylidene) phthalides and 3-substituted isocoumarins starting from methyl 2-hydroxybenzoates
(Z)-3-(1-Alkylidene) phthalides and 3-substituted isocoumarins, which include compounds bearing a substituent on their benzene ring, have been selectively and efficiently synthesized by a new protocol which involves:(i) the conversion of methyl 2- hydroxybenzoates into the corresponding nonaflates;(ii) Pd-catalyzed alkynylation reactions of these derivatives;(iii) the conversion of the so obtained methyl 2-(1-alkynyl) benzoates ...
