Tetrahedron Letters

Indium/copper-mediated conjugate addition of unactivated alkyl iodides to α, β-unsaturated carbonyl compounds in water

ZL Shen, HL Cheong, TP Loh

文献索引：Shen, Zhi-Liang; Cheong, Hao-Lun; Loh, Teck-Peng Tetrahedron Letters, 2009 , vol. 50, # 9 p. 1051 - 1054

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被引用次数: 18

摘要

An efficient method for the conjugate addition of unactivated alkyl iodides to α, β-unsaturated carbonyl compounds using indium/copper in water is described. The reactions proceed more efficiently in water than in organic solvents. In, CuI, and InCl3 are all essential for efficient reaction. Formation of a symmetrical vic-diarylalkane is observed when an aryl- substituted alkene is used as substrate.