Syntheses of Two Cytotoxic Sinapyl Alcohol Derivatives and Isolation of Four New Related Compounds from Ligularia n elumbifolia

Y Zhao, X Hao, W Lu, J Cai, H Yu…

文献索引：Zhao, Yu; Hao, Xiaojiang; Lu, Wei; Cai, Junchao; Yu, Hong; Sevenet, Thierry; Gueritte, Francoise Journal of Natural Products, 2002 , vol. 65, # 6 p. 902 - 908

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被引用次数: 18

摘要

Phytochemical reinvestigation on Ligularia nelumbifolia afforded four novel sinapyl alcohol analogues named nelumols BE (1-4) and three known sinapyl alcohol derivatives (5-7). Their structures were elucidated by NMR techniques. Total syntheses of cytotoxic geranyloxy sinapyl alcohol (6) and geranyloxy sinapyl aldehyde (7) were carried out via two different paths. The 4-O-benzyl-substituted analogues (20 and 27) as well as the 4-O-(2- ...