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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis and antibacterial activity of 2, 2'-dithiobis (benzamide) derivatives against Mycobacterium species

R Okachi, H Niino, K Kitaura, K Mineura…

文献索引：Okachi, Ryo; Niino, Hideki; Kitaura, Kozo; Mineura, Kazuyuki; Nakamizo, Yoshinobu; et al. Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1772 - 1779

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被引用次数: 36

摘要

A series of compounds, which are analogues of 2, 2 '-dithiobis (benzamide), were synthesized and tested for in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv including resistant strains against streptomycin, kanamycin, or isonicotinic acid hydrazide. MICs of these compounds against atypical mycobacteria, Mycobacterium kansasii and Mycobacterium intracellulare were also examined. Structure-activity ...

2,2-二硫二苯甲酰氯结构式

2,2-二硫二苯甲酰氯

二正丁胺结构式

~93%

N,N-dibutyl-2-[[2-(dibutylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N,N-dibutyl-2-[...

2,2-二硫二苯甲酰氯结构式

2,2-二硫二苯甲酰氯

phthalimide结构式

~79%

2-[2-[[2-(1,3-dioxoisoindole-2-carbonyl)phenyl]disulfanyl]benzoyl]isoindole-1,3-dione结构式

2-[2-[[2-(1,3-d...

2, 2’-二硫代二苯甲酸(DTSA)结构式

2, 2’-二硫代二苯甲酸(DTSA)

~%

2-[2-[[2-(1,3-dioxoisoindole-2-carbonyl)phenyl]disulfanyl]benzoyl]isoindole-1,3-dione结构式

2-[2-[[2-(1,3-d...

2,2-二硫二苯甲酰氯结构式

2,2-二硫二苯甲酰氯

二苯胺结构式

~58%

2-[[2-(diphenylcarbamoyl)phenyl]disulfanyl]-N,N-diphenylbenzamide结构式

2-[[2-(diphenyl...

2, 2’-二硫代二苯甲酸(DTSA)结构式

2, 2’-二硫代二苯甲酸(DTSA)

~%

2-[[2-(diphenylcarbamoyl)phenyl]disulfanyl]-N,N-diphenylbenzamide结构式

2-[[2-(diphenyl...

N-(2-hydroxyethyl)-2-[[2-(2-hydroxyethylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-(2-hydroxyeth...

十二酰氯结构式

~%

2-[[2-[[2-(2-dodecanoyloxyethylcarbamoyl)phenyl]disulfanyl]benzoyl]amino]ethyl dodecanoate结构式

2-[[2-[[2-(2-do...

2,2-二硫二苯甲酰氯结构式

2,2-二硫二苯甲酰氯

3,5-diethylaniline结构式

3,5-diethylaniline

~73%

N-(3,5-diethylphenyl)-2-[[2-[(3,5-diethylphenyl)carbamoyl]phenyl]disulfanyl]benzamide结构式

N-(3,5-diethylp...

2, 2’-二硫代二苯甲酸(DTSA)结构式

2, 2’-二硫代二苯甲酸(DTSA)

~%

N-(3,5-diethylphenyl)-2-[[2-[(3,5-diethylphenyl)carbamoyl]phenyl]disulfanyl]benzamide结构式

N-(3,5-diethylp...

2,2-二硫二苯甲酰氯结构式

2,2-二硫二苯甲酰氯

1-氨基-4-氯萘结构式

1-氨基-4-氯萘

~79%

N-(4-chloronaphthalen-1-yl)-2-[[2-[(4-chloronaphthalen-1-yl)carbamoyl]phenyl]disulfanyl]benzamide结构式

N-(4-chloronaph...

2, 2’-二硫代二苯甲酸(DTSA)结构式

2, 2’-二硫代二苯甲酸(DTSA)

~%

N-(4-chloronaphthalen-1-yl)-2-[[2-[(4-chloronaphthalen-1-yl)carbamoyl]phenyl]disulfanyl]benzamide结构式

N-(4-chloronaph...

2,2-二硫二苯甲酰氯结构式

2,2-二硫二苯甲酰氯

4-氨甲基哌啶结构式

4-氨甲基哌啶

~74%

N-(piperidin-4-ylmethyl)-2-[[2-(piperidin-4-ylmethylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-(piperidin-4-...

2, 2’-二硫代二苯甲酸(DTSA)结构式

2, 2’-二硫代二苯甲酸(DTSA)

~%

N-(piperidin-4-ylmethyl)-2-[[2-(piperidin-4-ylmethylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-(piperidin-4-...

2,2'-dithiobis(N-2-hydroxypropylbenzamide)结构式

2,2'-dithiobis(...

~%

2-(2-hydroxypropyl)-1,2-benzothiazol-3-one结构式

2-(2-hydroxypro...

2,2-二硫二苯甲酰氯结构式

2,2-二硫二苯甲酰氯

糠胺结构式

~89%

N-(furan-2-ylmethyl)-2-[[2-(furan-2-ylmethylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-(furan-2-ylme...

2, 2’-二硫代二苯甲酸(DTSA)结构式

2, 2’-二硫代二苯甲酸(DTSA)

~%

N-(furan-2-ylmethyl)-2-[[2-(furan-2-ylmethylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-(furan-2-ylme...

2,2-二硫二苯甲酰氯结构式

2,2-二硫二苯甲酰氯

1-甲基-3-苯基丙胺结构式

1-甲基-3-苯基丙胺

~87%

N-(4-phenylbutan-2-yl)-2-[[2-(4-phenylbutan-2-ylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-(4-phenylbuta...

2, 2’-二硫代二苯甲酸(DTSA)结构式

2, 2’-二硫代二苯甲酸(DTSA)

~%

N-(4-phenylbutan-2-yl)-2-[[2-(4-phenylbutan-2-ylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-(4-phenylbuta...

N-(2-hydroxyethyl)-2-[[2-(2-hydroxyethylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-(2-hydroxyeth...

棕榈酰氯结构式

~%

2-[[2-[[2-(2-hexadecanoyloxyethylcarbamoyl)phenyl]disulfanyl]benzoyl]amino]ethyl hexadecanoate结构式

2-[[2-[[2-(2-he...

N-(3-hydroxypropyl)-2-[[2-(3-hydroxypropylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-(3-hydroxypro...

棕榈酰氯结构式

~%

3-[[2-[[2-(3-pentadecanoyloxypropylcarbamoyl)phenyl]disulfanyl]benzoyl]amino]propyl hexadecanoate结构式

3-[[2-[[2-(3-pe...

2,2-二硫二苯甲酰氯结构式

2,2-二硫二苯甲酰氯

2-氨基3-羟基萘结构式

2-氨基3-羟基萘

~78%

N-(3-hydroxynaphthalen-2-yl)-2-[[2-[(3-hydroxynaphthalen-2-yl)carbamoyl]phenyl]disulfanyl]benzamide结构式

N-(3-hydroxynap...

2, 2’-二硫代二苯甲酸(DTSA)结构式

2, 2’-二硫代二苯甲酸(DTSA)

~%

N-(3-hydroxynaphthalen-2-yl)-2-[[2-[(3-hydroxynaphthalen-2-yl)carbamoyl]phenyl]disulfanyl]benzamide结构式

N-(3-hydroxynap...

2,2-二硫二苯甲酰氯结构式

2,2-二硫二苯甲酰氯

Benzenesulfonamide,4-amino-N-2-benzothiazolyl-结构式

Benzenesulfonam...

~76%

N-[4-(1,3-benzothiazol-2-ylsulfamoyl)phenyl]-2-[[2-[[4-(1,3-benzothiazol-2-ylsulfamoyl)phenyl]carbamoyl]phenyl]disulfanyl]benzamide结构式

N-[4-(1,3-benzo...

2, 2’-二硫代二苯甲酸(DTSA)结构式

2, 2’-二硫代二苯甲酸(DTSA)

~%

N-[4-(1,3-benzothiazol-2-ylsulfamoyl)phenyl]-2-[[2-[[4-(1,3-benzothiazol-2-ylsulfamoyl)phenyl]carbamoyl]phenyl]disulfanyl]benzamide结构式

N-[4-(1,3-benzo...

2,2-二硫二苯甲酰氯结构式

2,2-二硫二苯甲酰氯

1-氨基-4-溴萘结构式

1-氨基-4-溴萘

~93%

N-(4-bromonaphthalen-1-yl)-2-[[2-[(4-bromonaphthalen-1-yl)carbamoyl]phenyl]disulfanyl]benzamide结构式

N-(4-bromonapht...

2, 2’-二硫代二苯甲酸(DTSA)结构式

2, 2’-二硫代二苯甲酸(DTSA)

~%

N-(4-bromonaphthalen-1-yl)-2-[[2-[(4-bromonaphthalen-1-yl)carbamoyl]phenyl]disulfanyl]benzamide结构式

N-(4-bromonapht...

十二酰氯结构式

2,2'-dithiobis(N-2-hydroxypropylbenzamide)结构式

2,2'-dithiobis(...

~%

1-[[2-[[2-(2-dodecanoyloxypropylcarbamoyl)phenyl]disulfanyl]benzoyl]amino]propan-2-yl dodecanoate结构式

1-[[2-[[2-(2-do...

2,2'-dithiobis(N-2-hydroxypropylbenzamide)结构式

2,2'-dithiobis(...

棕榈酰氯结构式

~%

1-[[2-[[2-(2-hexadecanoyloxypropylcarbamoyl)phenyl]disulfanyl]benzoyl]amino]propan-2-yl hexadecanoate结构式

1-[[2-[[2-(2-he...

2,2-二硫二苯甲酰氯结构式

2,2-二硫二苯甲酰氯

2-乙基己胺结构式

~94%

N-(2-ethylhexyl)-2-[[2-(2-ethylhexylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-(2-ethylhexyl...

2, 2’-二硫代二苯甲酸(DTSA)结构式

2, 2’-二硫代二苯甲酸(DTSA)

~%

N-(2-ethylhexyl)-2-[[2-(2-ethylhexylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-(2-ethylhexyl...

N-(2-hydroxyethyl)-2-[[2-(2-hydroxyethylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-(2-hydroxyeth...

异氰酸乙酯结构式

异氰酸乙酯

~92%

2-[[2-[[2-[2-(ethylcarbamoyloxy)ethylcarbamoyl]phenyl]disulfanyl]benzoyl]amino]ethyl N-ethylcarbamate结构式

2-[[2-[[2-[2-(e...

2,2-二硫二苯甲酰氯结构式

2,2-二硫二苯甲酰氯

2-氨基-2-乙基-1,3-丙二醇结构式

2-氨基-2-乙基-1,3-丙二醇

~88%

N-[1-hydroxy-2-(hydroxymethyl)butan-2-yl]-2-[[2-[[1-hydroxy-2-(hydroxymethyl)butan-2-yl]carbamoyl]phenyl]disulfanyl]benzamide结构式

N-[1-hydroxy-2-...

2, 2’-二硫代二苯甲酸(DTSA)结构式

2, 2’-二硫代二苯甲酸(DTSA)

~%

N-[1-hydroxy-2-(hydroxymethyl)butan-2-yl]-2-[[2-[[1-hydroxy-2-(hydroxymethyl)butan-2-yl]carbamoyl]phenyl]disulfanyl]benzamide结构式

N-[1-hydroxy-2-...

2,2-二硫二苯甲酰氯结构式

2,2-二硫二苯甲酰氯

1-萘甲胺结构式

~92%

N-(naphthalen-1-ylmethyl)-2-[[2-(naphthalen-1-ylmethylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-(naphthalen-1...

2, 2’-二硫代二苯甲酸(DTSA)结构式

2, 2’-二硫代二苯甲酸(DTSA)

~%

N-(naphthalen-1-ylmethyl)-2-[[2-(naphthalen-1-ylmethylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-(naphthalen-1...

2,2-二硫二苯甲酰氯结构式

2,2-二硫二苯甲酰氯

8-氨基喹啉结构式

~85%

N-quinolin-8-yl-2-[[2-(quinolin-8-ylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-quinolin-8-yl...

2, 2’-二硫代二苯甲酸(DTSA)结构式

2, 2’-二硫代二苯甲酸(DTSA)

~%

N-quinolin-8-yl-2-[[2-(quinolin-8-ylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-quinolin-8-yl...

N-(3-hydroxypropyl)-2-[[2-(3-hydroxypropylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-(3-hydroxypro...

丁酰氯结构式

~%

3-[[2-[[2-(3-butanoyloxypropylcarbamoyl)phenyl]disulfanyl]benzoyl]amino]propyl butanoate结构式

3-[[2-[[2-(3-bu...

2,2-二硫二苯甲酰氯结构式

2,2-二硫二苯甲酰氯

2-硝基-1-萘胺结构式

2-硝基-1-萘胺

~79%

N-(2-nitronaphthalen-1-yl)-2-[[2-[(2-nitronaphthalen-1-yl)carbamoyl]phenyl]disulfanyl]benzamide结构式

N-(2-nitronapht...

2, 2’-二硫代二苯甲酸(DTSA)结构式

2, 2’-二硫代二苯甲酸(DTSA)

~%

N-(2-nitronaphthalen-1-yl)-2-[[2-[(2-nitronaphthalen-1-yl)carbamoyl]phenyl]disulfanyl]benzamide结构式

N-(2-nitronapht...

N-(3-hydroxypropyl)-2-[[2-(3-hydroxypropylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-(3-hydroxypro...

庚酰氯结构式

~%

3-[[2-[[2-(3-heptanoyloxypropylcarbamoyl)phenyl]disulfanyl]benzoyl]amino]propyl heptanoate结构式

3-[[2-[[2-(3-he...

N-(3-hydroxypropyl)-2-[[2-(3-hydroxypropylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-(3-hydroxypro...

辛酰氯结构式

~%

3-[[2-[[2-(3-octanoyloxypropylcarbamoyl)phenyl]disulfanyl]benzoyl]amino]propyl octanoate结构式

3-[[2-[[2-(3-oc...

2,2-二硫二苯甲酰氯结构式

2,2-二硫二苯甲酰氯

1-氨基-2-丁醇结构式

1-氨基-2-丁醇

~87%

N-(2-hydroxybutyl)-2-[[2-(2-hydroxybutylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-(2-hydroxybut...

2, 2’-二硫代二苯甲酸(DTSA)结构式

2, 2’-二硫代二苯甲酸(DTSA)

~%

N-(2-hydroxybutyl)-2-[[2-(2-hydroxybutylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-(2-hydroxybut...

2,2-二硫二苯甲酰氯结构式

2,2-二硫二苯甲酰氯

氨基乙醛缩二甲醇结构式

氨基乙醛缩二甲醇

~76%

N-(2,2-dimethoxyethyl)-2-[[2-(2,2-dimethoxyethylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-(2,2-dimethox...

2, 2’-二硫代二苯甲酸(DTSA)结构式

2, 2’-二硫代二苯甲酸(DTSA)

~%

N-(2,2-dimethoxyethyl)-2-[[2-(2,2-dimethoxyethylcarbamoyl)phenyl]disulfanyl]benzamide结构式

N-(2,2-dimethox...

2,2-二硫二苯甲酰氯结构式

2,2-二硫二苯甲酰氯

3-氨基-9-乙基咔唑结构式

3-氨基-9-乙基咔唑

~66%

N-(9-ethylcarbazol-3-yl)-2-[[2-[(9-ethylcarbazol-3-yl)carbamoyl]phenyl]disulfanyl]benzamide结构式

N-(9-ethylcarba...

2, 2’-二硫代二苯甲酸(DTSA)结构式

2, 2’-二硫代二苯甲酸(DTSA)

~%

N-(9-ethylcarbazol-3-yl)-2-[[2-[(9-ethylcarbazol-3-yl)carbamoyl]phenyl]disulfanyl]benzamide结构式

N-(9-ethylcarba...

2,2-二硫二苯甲酰氯结构式

2,2-二硫二苯甲酰氯

2-胺基乙酸乙酯结构式

2-胺基乙酸乙酯

~91%

ethyl 2-[[2-[[2-[(2-ethoxy-2-oxoethyl)carbamoyl]phenyl]disulfanyl]benzoyl]amino]acetate结构式

ethyl 2-[[2-[[2...