Luminescence

Study on the interaction between human serum albumin and a novel bioactive acridine derivative using optical spectroscopy

L Chen, M Wu, X Lin, Z Xie

文献索引：Chen, Liangbi; Wu, Menghui; Lin, Xucong; Xie, Zenghong Luminescence, 2011 , vol. 26, # 3 p. 172 - 177

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被引用次数: 8

摘要

Abstract The interaction of a novel bioactive agent N-{[N-(2-dimethylamino) ethyl] acridine-4- carboxamide}-α-alanine [N-(ACR-4-CA)-α-ALA] with human serum albumin (HSA) was investigated by fluorescence spectroscopy, UV–vis absorption and circular dichroism spectrophotometric techniques under simulative physiological conditions. The fluorescence quenching of HSA by addition of N-(ACR-4-CA)-α-ALA is due to static quenching and ...