2-{2-[3-(Pyridin-3-yloxy) phenyl]-2H-tetrazol-5-yl} pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist

D Huang, SF Poon, DF Chapman, J Chung…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 22 p. 5473 - 5476

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被引用次数: 26

摘要

... Bioorganic & Medicinal Chemistry Letters. ... a Department of Medicinal Chemistry, Merck Research ... As shown in Scheme 3, for the N-linked biaryls 13 and 15, the fourth ring was appended using palladium-catalyzed heteroatom cross-coupling chemistry between an aryl iodide ...