Synthesis and antitubulin activity of N 1-and N4-substituted 3, 5-dinitro sulfanilamides against African Trypanosomes and Leishmania

…, M Mollet, G Riccio, R Brun, KA Werbovetz

文献索引：Bhattacharya, Gautam; Herman, Johnathan; Delfin, Dawn; Salem, Manar M.; Barszcz, Todd; Mollet, Mike; Riccio, Guy; Brun, Reto; Werbovetz, Karl A. Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1823 - 1832

全文：HTML全文

被引用次数: 53

摘要

Thirty analogues of N 1-phenyl-3, 5-dinitro-N 4, N 4-di-n-propylsulfanilamide (GB-II-5, compound 3), a new antikinetoplastid antimitotic agent, have been synthesized and evaluated. The addition of simple functional groups to the N1 aromatic ring generally decreases antiparasitic and antimitotic potency, but placement of a dibutyl substituent at the N4 nitrogen to give N 1-phenyl-3, 5-dinitro-N 4, N 4-di-n-butylsulfanilamide (compound 35 ...