Synthesis of a sialyl lewisX mimetic conjugated with DTPA, potential ligand of new contrast agents for medical imaging

Y Fu, S Laurent, RN Muller

文献索引：Fu, Yanjun; Laurent, Sophie; Muller, Robert N. European Journal of Organic Chemistry, 2002 , # 23 p. 3966 - 3973

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被引用次数: 33

摘要

Abstract The structure of a mimetic of sialyl Lewis X, namely 3-[2-(α-D-mannopyranosyloxy) phenyl] phenylacetic acid, was coupled to diethylenetriaminepentaacetic acid (DTPA) via a flexible alkyl spacer and the amide linkage. The overall yield of the eleven-step synthesis starting from 3-bromophenylacetic acid was 4− 8%. This new ligand is expected to target inflammation sites through specific interactions with selectins, the adhesion molecules ...