Synthesis of Phenylboronic Acids in Continuous Flow by Means of a Multijet Oscillating Disc Reactor System Operating at Cryogenic Temperatures

D Sleveland, HR Bjørsvik

文献索引：Sleveland, Dagfinn; Bjorsvik, Hans-Rene Organic Process Research and Development, 2012 , vol. 16, # 5 p. 1121 - 1130

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被引用次数: 14

摘要

A multijet oscillating disk (MJOD) millireactor system suitable for operating at cryogenic temperatures has been developed, assembled, and investigated. This new reactor system (cryoMJOD) was realized with the purpose to prepare various phenylboronic acids in a continuous two (three)-step telescoped synthetic process at temperatures in the interval− 50 to− 75° C. In this process, n-butyllithium was reacted with a phenylbromide to provide the ...