Synthesis and biological properties of (carboxyalkyl) amino-substituted bicyclic lactam inhibitors of angiotensin converting enzyme

…, JL Stanton, M Desai, JE Babiarz, BM Finn

文献索引：Watthey; Stanton; Desai; Babiarz; Finn Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1511 - 1516

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被引用次数: 108

摘要

Division, CIBA-GEIGY Corp, Summit, NJ 07901. lower doses than originally specified2 and that, under these circumstances, side effects are effectively restricted to a small subgroup of patients having serious complications prior to initiation of the therapy. Studies reported on the clinical application of the non-thiol inhibitor enalapril (2a) are not as extensive as those with captopril, but indications are that the incidence of side effects is In a recent paper, 4 ...