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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Potential anticonvulsants: Substituted N-benzylidene derivatives of 10-(4-aminopiperazino)-10, 11-dihydrodibenzo [b, f] thiepins

V Bártl, J Holubek, E Svátek…

文献索引：Bartl; Holubek; Svatek; et al. Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 4 p. 1173 - 1186

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被引用次数: 3

摘要

Abstract Reactions of 10-(4-aminopiperazino)-10, 11-dihydrodibenzo [b, f] thiepins XIVa- XIVd with benzaldehyde, 3, 4-dimethoxybenzaldehyde, 4-dimethylaminobenzaldehyde, salicylaldehyde, 3-ethoxy-4-hydroxybenzaldehyde, 2-(2-dimethylaminoethoxy) benzaldehyde, 3-(2-dimethylaminoethoxy) benzaldehyde and 3-ethoxy-4-(2- dimethylaminoethoxy) benzaldehyde afforded a series of 19 hydrazones IIIa-Xc. Some of ...

2-chloro-10-(4-nitrosopiperazino)-10,11-dihydrodibenzo(b,f)thiepin结构式

2-chloro-10-(4-...

~%

(4E)-4-[[[4-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-6-yl)piperazin-1-yl]amino]methylidene]-2-ethoxycyclohexa-2,5-dien-1-one结构式

(4E)-4-[[[4-(3-...

2-Chloro-10-piperazino-10,11-dihydrodibenzo[b,f]thiepin结构式

2-Chloro-10-pip...

~%

(4E)-4-[[[4-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-6-yl)piperazin-1-yl]amino]methylidene]-2-ethoxycyclohexa-2,5-dien-1-one结构式

(4E)-4-[[[4-(3-...

乙基香兰素结构式

乙基香兰素

10-(4-aminopiperazino)-2-chloro-10,11-dihydrodibenzo(b,f)thiepin结构式

10-(4-aminopipe...

~%

(4E)-4-[[[4-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-6-yl)piperazin-1-yl]amino]methylidene]-2-ethoxycyclohexa-2,5-dien-1-one结构式

(4E)-4-[[[4-(3-...

4-(10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-piperazin-1-ylamine结构式

4-(10,11-dihydr...

水杨醛结构式

~89%

2-(((4-(10,11-Dihydrodibenzo(b,f)thiepin-10-yl)-1-piperazinyl)imino)me thyl)phenol结构式

2-(((4-(10,11-D...

乙基香兰素结构式

乙基香兰素

2-氯-N,N-二甲基乙胺结构式

2-氯-N,N-二甲基乙胺

~50%

4-[2-(dimethylamino)ethoxy]-3-ethoxybenzaldehyde结构式

4-[2-(dimethyla...

间羟基苯甲醛结构式

间羟基苯甲醛

2-氯-N,N-二甲基乙胺结构式

2-氯-N,N-二甲基乙胺

~54%

3-[2-(二甲基氨基)乙氧基]苯甲醛结构式

3-[2-(二甲基氨基)乙氧基]苯甲醛

10-(4-aminopiperazino)-2-chloro-10,11-dihydrodibenzo(b,f)thiepin结构式

10-(4-aminopipe...

苯甲醛结构式

~82%

1-Piperazinamine, 4-(2-chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yl)- N-(phenylmethylene)-结构式

1-Piperazinamin...

2-chloro-10-(4-nitrosopiperazino)-10,11-dihydrodibenzo(b,f)thiepin结构式

2-chloro-10-(4-...

~%

1-Piperazinamine, 4-(2-chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yl)- N-(phenylmethylene)-结构式

1-Piperazinamin...

2-Chloro-10-piperazino-10,11-dihydrodibenzo[b,f]thiepin结构式

2-Chloro-10-pip...

~%

1-Piperazinamine, 4-(2-chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yl)- N-(phenylmethylene)-结构式

1-Piperazinamin...

10-(4-aminopiperazino)-2,8-chloro-10,11-dihydrodibenzo(b,f)thiepin结构式

10-(4-aminopipe...

苯甲醛结构式

~72%

1-Piperazinamine, 4-(2,8-dichloro-10,11-dihydrodibenzo(b,f)thiepin-10- yl)-N-(phenylmethylene)-结构式

1-Piperazinamin...

2,8-dichloro-10,11-dihydro-dibenzo[b,f]thiepin-10-ol结构式

2,8-dichloro-10...

~%

1-Piperazinamine, 4-(2,8-dichloro-10,11-dihydrodibenzo(b,f)thiepin-10- yl)-N-(phenylmethylene)-结构式

1-Piperazinamin...

2,8-dichloro-10-piperazino-10,11-dihydrodibenzo(b,f)thiepin结构式

2,8-dichloro-10...

~%

1-Piperazinamine, 4-(2,8-dichloro-10,11-dihydrodibenzo(b,f)thiepin-10- yl)-N-(phenylmethylene)-结构式

1-Piperazinamin...

2,8-dichloro-10-(4-nitrosopiperazino)-10,11-dihydrodibenzo(b,f)thiepin结构式

2,8-dichloro-10...

~%

1-Piperazinamine, 4-(2,8-dichloro-10,11-dihydrodibenzo(b,f)thiepin-10- yl)-N-(phenylmethylene)-结构式

1-Piperazinamin...

2,8-dichloro-10-(4-ethoxycarbonylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin结构式

2,8-dichloro-10...

~%

1-Piperazinamine, 4-(2,8-dichloro-10,11-dihydrodibenzo(b,f)thiepin-10- yl)-N-(phenylmethylene)-结构式

1-Piperazinamin...

未登录结构式

~%

1-Piperazinamine, 4-(2,8-dichloro-10,11-dihydrodibenzo(b,f)thiepin-10- yl)-N-(phenylmethylene)-结构式

1-Piperazinamin...

10-(4-aminopiperazino)-2-chloro-10,11-dihydrodibenzo(b,f)thiepin结构式

10-(4-aminopipe...

藜芦醛； 3,4-二甲氧基苯甲醛结构式

藜芦醛； 3,4-二甲氧基苯甲醛

~84%

1-Piperazinamine, 4-(2-chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yl)- N-((3,4-dimethoxyphenyl)methylene)-结构式

1-Piperazinamin...

2-chloro-10-(4-nitrosopiperazino)-10,11-dihydrodibenzo(b,f)thiepin结构式

2-chloro-10-(4-...

~%

1-Piperazinamine, 4-(2-chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yl)- N-((3,4-dimethoxyphenyl)methylene)-结构式

1-Piperazinamin...

2-Chloro-10-piperazino-10,11-dihydrodibenzo[b,f]thiepin结构式

2-Chloro-10-pip...

~%

1-Piperazinamine, 4-(2-chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yl)- N-((3,4-dimethoxyphenyl)methylene)-结构式

1-Piperazinamin...

4-(10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-piperazin-1-ylamine结构式

4-(10,11-dihydr...

对二甲氨基苯甲醛结构式

对二甲氨基苯甲醛

~85%

1-Piperazinamine, 4-(10,11-dihydrodibenzo(b,f)thiepin-10-yl)-N-((4-(di methylamino)phenyl)methylene)-结构式

1-Piperazinamin...

4-(10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-piperazin-1-ylamine结构式

4-(10,11-dihydr...

苯甲醛结构式

~89%

1-Piperazinamine, 4-(10,11-dihydrodibenzo(b,f)thiepin-10-yl)-N-(phenyl methylene)-结构式

1-Piperazinamin...

11-(4-aminopiperazino)-2-chloro-10,11-dihydrodibenzo(b,f)thiepin结构式

11-(4-aminopipe...

苯甲醛结构式

~82%

1-Piperazinamine, 4-(8-chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yl)- N-(phenylmethylene)-结构式

1-Piperazinamin...

2-chloro-11-(4-nitrosopiperazino)-10,11-dihydrodibenzo(b,f)thiepin结构式

2-chloro-11-(4-...

~%

1-Piperazinamine, 4-(8-chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yl)- N-(phenylmethylene)-结构式

1-Piperazinamin...

1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)piperazine结构式

1-(8-chloro-10,...

~%

1-Piperazinamine, 4-(8-chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yl)- N-(phenylmethylene)-结构式

1-Piperazinamin...

10-(4-aminopiperazino)-2,8-chloro-10,11-dihydrodibenzo(b,f)thiepin结构式

10-(4-aminopipe...

水杨醛结构式

~68%

(6E)-6-[[[4-(3,8-dichloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)piperazin-1-yl]amino]methylidene]cyclohexa-2,4-dien-1-one结构式

(6E)-6-[[[4-(3,...

2,8-dichloro-10,11-dihydro-dibenzo[b,f]thiepin-10-ol结构式

2,8-dichloro-10...

~%

(6E)-6-[[[4-(3,8-dichloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)piperazin-1-yl]amino]methylidene]cyclohexa-2,4-dien-1-one结构式

(6E)-6-[[[4-(3,...

2,8-dichloro-10-piperazino-10,11-dihydrodibenzo(b,f)thiepin结构式

2,8-dichloro-10...

~%

(6E)-6-[[[4-(3,8-dichloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)piperazin-1-yl]amino]methylidene]cyclohexa-2,4-dien-1-one结构式

(6E)-6-[[[4-(3,...

2,8-dichloro-10-(4-nitrosopiperazino)-10,11-dihydrodibenzo(b,f)thiepin结构式

2,8-dichloro-10...

~%

(6E)-6-[[[4-(3,8-dichloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)piperazin-1-yl]amino]methylidene]cyclohexa-2,4-dien-1-one结构式

(6E)-6-[[[4-(3,...

2,8-dichloro-10-(4-ethoxycarbonylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin结构式

2,8-dichloro-10...

~%

(6E)-6-[[[4-(3,8-dichloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)piperazin-1-yl]amino]methylidene]cyclohexa-2,4-dien-1-one结构式

(6E)-6-[[[4-(3,...

未登录结构式

~%

(6E)-6-[[[4-(3,8-dichloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)piperazin-1-yl]amino]methylidene]cyclohexa-2,4-dien-1-one结构式

(6E)-6-[[[4-(3,...