Total synthesis of amphotericin B

KC Nicolaou, RA Daines, TK Chakraborty…

文献索引：Nicolaou, K. C.; Daines, R. A.; Chakraborty, T. K.; Ogawa, Y. Journal of the American Chemical Society, 1987 , vol. 109, # 9 p. 2821 - 2822

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被引用次数: 60

摘要

OH" 2 amphotericin B (1) 3-5 in its naturally occurring enantiomeric form. The thorny nature of an eventual total synthesis of this complex and widely used antibiotic has long been recognized, particularly in view of the glycosidation step. Justified concerns stemmed from (a) the rather labile nature of amphoteronolide B6 and arnphotericin B (1) and their derivatives,(b) the presence of a basic nitrogen in the carbohydrate moiety, and (c) the ...