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Synthesis of novel cationic lipids: effect of structural modification on the efficiency of gene transfer

JA Heyes, D Niculescu-Duvaz, RG Cooper…

文献索引:Journal of Medicinal Chemistry, , vol. 45, # 1 p. 99 - 114

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被引用次数: 166

摘要

... Journal of Medicinal Chemistry. ... The lipids were assayed in vitro for their ability to transfect cells with the lacZ gene. Chemical Syntheses. Diether Lipids. The diether lipids were synthesized via the synthetic route displayed in Figure 1. The chemistry of Carruthers et al. ...