Synthesis of novel cationic lipids: effect of structural modification on the efficiency of gene transfer

JA Heyes, D Niculescu-Duvaz, RG Cooper…

Index: Journal of Medicinal Chemistry, , vol. 45, # 1 p. 99 - 114

Full Text: HTML

Citation Number: 166

Abstract

... Journal of Medicinal Chemistry. ... The lipids were assayed in vitro for their ability to transfect cells with the lacZ gene. Chemical Syntheses. Diether Lipids. The diether lipids were synthesized via the synthetic route displayed in Figure 1. The chemistry of Carruthers et al. ...

Poly (glycidyl amine) and copolymers with glycidol and glyci...

[Meyer, Joerg; Keul, Helmut; Moeller, Martin Macromolecules, 2011 , vol. 44, # 11 p. 4082 - 4091]

Synthesis of a series of sulfinic acid analogs of GABA and e...

[Carruthers, Nicholas I.; Spitler, James M.; Wong, Shing-Chun; Blythin, David J.; Chen, Xiao; Shue, Ho-Jane; She, Hoyan S.; Lee, Joe F.; Rizzo, Charles; Ting, Pauline C.; West Jr., Robert E. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 21 p. 3059 - 3064]

Highly Regioselective and Efficient Synthesis of Aminoepoxid...

[Pace, Vittorio; Hoyos, Pilar; Sinisterra, Jose Vicente; Alcantara, Andres R.; Holzer, Wolfgang Synlett, 2011 , # 13 p. 1831 - 1834]

Organic reactions in ionic liquids: N-alkylation of cyclic i...

[Hu, Yi; Chen, Zhen-Chu; Le, Zhang-Gao; Zheng, Qin-Guo Journal of Chemical Research, 2004 , # 4 p. 276 - 278]

2-Methyltetrahydrofuran as a suitable green solvent for phth...

[Green Chemistry, , vol. 12, # 8 p. 1380 - 1382]