Structure–activity relationship of salicylic acid derivatives on inhibition of TNF-α dependent NFκB activity: Implication on anti-inflammatory effect of N-(5- …
J Kim, S Kang, S Hong, S Yum, YM Kim…
文献索引：Kim, Jihye; Kang, Sookjin; Hong, Sungchae; Yum, Soowhan; Kim, Young Mi; Jung, Yunjin European Journal of Medicinal Chemistry, 2012 , vol. 48, p. 36 - 44
To develop a more potent NFκB inhibitor from salicylic acid which is known to inhibit activity of NFκB, a transcription factor regulating genes involved in immunity, inflammation and tumorigenesis, derivatives of salicylic acid (SA) where the 5 position, carboxyl or hydroxyl group was modified were treated in HCT116 cells transfected with an NFκB dependent luciferase gene and LPS-stimulated RAW264. 7 cells. Amidation of the carboxylic group or ...
