Tetrahedron

Copper (II) triflate-catalyzed reduction of carboxylic acids to alcohols and reductive etherification of carbonyl compounds

YJ Zhang, W Dayoub, GR Chen, M Lemaire

文献索引：Zhang, Yin-Jie; Dayoub, Wissam; Chen, Guo-Rong; Lemaire, Marc Tetrahedron, 2012 , vol. 68, # 36 p. 7400 - 7407

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被引用次数: 17

摘要

A protocol is described for the reduction of carboxylic acids to primary alcohols using 1, 1, 3, 3-tetramethyldisiloxane (TMDS) and a catalytic amount of Cu (OTf) 2. Aliphatic as well as aromatic carboxylic acids are reduced in high selectivity and good yields. TMDS/Cu (OTf) 2 has also been found to be an efficient catalytic reducing system for the preparation of symmetrical ethers from carbonyl compounds under mild conditions.