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Medicinal Chemistry Research

Synthesis and QSAR studies of some novel disubstituted 1, 2, 4-triazoles as antimicrobial agents

SS Panda, SC Jain

文献索引:Panda, Siva S.; Jain, Subhash C. Medicinal Chemistry Research, 2014 , vol. 23, # 2 p. 848 - 861

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被引用次数: 2

摘要

Abstract Disubstituted 1, 2, 4-triazoles 3a–k, 4a–k, and 6a–k have been synthesized from anthranilic acid and nicotinic acid, respectively, through a multi-step reaction sequence via their hydrazides. Synthesized compounds were evaluated for their in vitro antimicrobial activity against two gram-positive bacteria (S. aureus and B. subtilis), three gram-negative bacteria (E. coli, S. typhi, and K. pneumonia) as well as four fungi (A. niger, A. fumigatus, A ...