The Synthesis of Stereodefined Trisubstituted Olefins From Olefin Templates Using Pd Catalysis–Synthesis of the Antihypertensive Isbogrel

LR Rogers, Z Konstantinou, M Reddy…

文献索引：Rogers, Lawrence R.; Konstantinou, Zissis; Reddy, Madhav; Organ, Michael G. European Journal of Organic Chemistry, 2011 , # 27 p. 5374 - 5382

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被引用次数: 1

摘要

Abstract A collection of highly functionalized, trisubstituted olefin building blocks (templates) have been developed for their Pd-catalyzed elaboration into more complex structures, including natural products and compounds of medicinal chemistry interest. The Pd-mediated transformations involve a combination of allylic substitution and cross-coupling reactions. The templates have been designed such that these processes proceed not only with a ...