Thromboxane synthetase inhibitors (TXSI). Design, synthesis, and evaluation of a novel series of. omega.-pyridylalkenoic acids

K Kato, S Ohkawa, S Terao, Z Terashita…

文献索引：Kato, Kaneyoshi; Ohkawa, Shigenori; Terao, Shinji; Terashita, Zen-ichi; Nishikawa, Kohei Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 287 - 294

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被引用次数: 123

摘要

A novel series of w-pyridylalkenoic acids has been prepared by applying the Wittig reaction. Modifications were made in the w-aryl moiety, the alkylene chain length, the a-methylene group adjacent to the carbonyl group, and the carboxyl group of the molecule. The compounds were tested as inhibitors of thromboxane synthetase in an in vitro assay and in ex vivo experiments with the rat. Most members of this new class of thromboxane ...