N-imidazolyl derivatives of the napththalene and chroman rings as thromboxane A 2 synthase inhibitors

P Cozzi, U Branzoli, G Carganico, C Ferti…

文献索引：Cozzi, P; Branzoli, U; Carganico, G; Ferti, C; Pillan, A; et al. European Journal of Medicinal Chemistry, 1991 , vol. 26, # 4 p. 423 - 433

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被引用次数: 9

摘要

Abstract A series of N-imidazol-1-yl derivatives of 1, 2-dihydronaphthalene, 1, 2, 3, 4- tetrahydronaphthalene, 2H-1-benzopyran and some related compounds were synthesized and tested as inhibitors of thromboxane A 2 synthase in ex vivo experiments with orally treated rats. Some compounds showed good activity which was confirmed in experiments in vitro in rabbit whole blood. Some structural requirements for significant TxA 2 synthase ...