e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

N-imidazolyl derivatives of the napththalene and chroman rings as thromboxane A 2 synthase inhibitors

P Cozzi, U Branzoli, G Carganico, C Ferti…

Index: Cozzi, P; Branzoli, U; Carganico, G; Ferti, C; Pillan, A; et al. European Journal of Medicinal Chemistry, 1991 , vol. 26, # 4 p. 423 - 433

Full Text: HTML

Citation Number: 9

Abstract

Abstract A series of N-imidazol-1-yl derivatives of 1, 2-dihydronaphthalene, 1, 2, 3, 4- tetrahydronaphthalene, 2H-1-benzopyran and some related compounds were synthesized and tested as inhibitors of thromboxane A 2 synthase in ex vivo experiments with orally treated rats. Some compounds showed good activity which was confirmed in experiments in vitro in rabbit whole blood. Some structural requirements for significant TxA 2 synthase ...

2-methyl-3-(1-imidazolyl)-2,3-dihydro-6-carboxy-4H-1-benzopyran-4-ol Structure

2-methyl-3-(1-i...

~82%

3-imidazol-1-yl-2-methyl-2H-chromene-6-carboxylic acid Structure

3-imidazol-1-yl...

Ethanol Structure

rolafagrel Structure

~74%

ethyl 7-imidazol-1-yl-5,6-dihydronaphthalene-2-carboxylate Structure

ethyl 7-imidazo...

2-(1-imidazolyl)-1,2,3,4-tetrahydro-7-carboxy-1-naphthalenol Structure

2-(1-imidazolyl...

~%

ethyl 7-imidazol-1-yl-5,6-dihydronaphthalene-2-carboxylate Structure

ethyl 7-imidazo...

ethyl 7-imidazol-1-yl-5,6-dihydronaphthalene-2-carboxylate Structure

ethyl 7-imidazo...

~89%

(7-imidazol-1-yl-5,6-dihydronaphthalen-2-yl)methanol Structure

(7-imidazol-1-y...

rolafagrel Structure

~%

(7-imidazol-1-yl-5,6-dihydronaphthalen-2-yl)methanol Structure

(7-imidazol-1-y...

2-(1-imidazolyl)-1,2,3,4-tetrahydro-7-carboxy-1-naphthalenol Structure

2-(1-imidazolyl...

~%

(7-imidazol-1-yl-5,6-dihydronaphthalen-2-yl)methanol Structure

(7-imidazol-1-y...

1-(6-bromo-3,4-dihydronaphthalen-2-yl)imidazole Structure

1-(6-bromo-3,4-...

~%

6-imidazol-1-yl-7,8-dihydronaphthalene-1-carboxylic acid Structure

6-imidazol-1-yl...

6-imidazol-1-yl-7,8-dihydronaphthalene-2-carbonitrile Structure

6-imidazol-1-yl...

~%

6-imidazol-1-yl-7,8-dihydronaphthalene-1-carboxylic acid Structure

6-imidazol-1-yl...

6-imidazol-1-yl-7,8-dihydronaphthalene-2-carboxamide Structure

6-imidazol-1-yl...

Copper cyanide Structure

1-(6-bromo-3,4-dihydronaphthalen-2-yl)imidazole Structure

1-(6-bromo-3,4-...

~%

6-imidazol-1-yl-7,8-dihydronaphthalene-2-carbonitrile Structure

6-imidazol-1-yl...

2-(1-imidazolyl)-1,2,3,4-tetrahydro-7-carboxy-1-naphthalenol Structure

2-(1-imidazolyl...

~%

7-imidazol-1-ylnaphthalene-2-carboxylic acid Structure

7-imidazol-1-yl...

N/A Structure

~%

7-imidazol-1-ylnaphthalene-2-carboxylic acid Structure

7-imidazol-1-yl...

rolafagrel Structure

~%

7-imidazol-1-ylnaphthalene-2-carboxylic acid Structure

7-imidazol-1-yl...

ethyl 7-imidazol-1-yl-5,6-dihydronaphthalene-2-carboxylate Structure

ethyl 7-imidazo...

~%

7-imidazol-1-ylnaphthalene-2-carboxylic acid Structure

7-imidazol-1-yl...

2-(1H-imidazol-1-yl)-6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol Structure

2-(1H-imidazol-...

~78%

1-(6-methoxy-3,4-dihydronaphthalen-2-yl)imidazole Structure

1-(6-methoxy-3,...

2-(1-imidazolyl)-1,2,3,4-tetrahydro-7-carboxy-1-naphthalenol Structure

2-(1-imidazolyl...

~72%

rolafagrel Structure

2-imidazol-1-yl-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol Structure

2-imidazol-1-yl...

~79%

1-(7-methoxy-3,4-dihydronaphthalen-2-yl)imidazole Structure

1-(7-methoxy-3,...

1-(7-methoxy-3,4-dihydronaphthalen-2-yl)imidazole Structure

1-(7-methoxy-3,...

~82%

1-(7-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)imidazole Structure

1-(7-methoxy-1,...

2-imidazol-1-yl-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol Structure

2-imidazol-1-yl...

~%

1-(7-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)imidazole Structure

1-(7-methoxy-1,...