4-Hydroxy-5, 6-dihydropyrones as inhibitors of HIV protease: the effect of heterocyclic substituents at C-6 on antiviral potency and pharmacokinetic parameters

SE Hagen, J Domagala, C Gajda…

文献索引：Journal of Medicinal Chemistry, , vol. 44, # 14 p. 2319 - 2332

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被引用次数: 53

摘要

... Journal of Medicinal Chemistry. ... Abstract. Abstract Image. Due largely to the emergence of multi-drug-resistant HIV strains, the development of new HIV protease inhibitors remains a high priority for the pharmaceutical industry. ...