Synthesis and cardiotonic activity of a series of substituted 4-alkyl-2 (1H)-quinazolinones

VT Bandurco, CF Schwender, SC Bell…

文献索引：Bandurco, Victor T.; Schwender, Charles F.; Bell, Stanley C.; Combs, Donald W.; Kanojia, Ramesh M.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1421 - 1426

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被引用次数: 33

摘要

The synthesis, cardiac fraction I11 cyclic nucleotide phosphodiesterase (PDE-111) inhibition, and positive inotropic activity of a series of 2 (1H)-quinazolinones are reported. A general synthesis of the series involved the cyclization of 2-aminoacetophenones with potassium cyanate in acetic acid. Modifications at the 4-position of the quinazoline nucleus were best achieved by formation of the intermediate W-acyl-p-phenylurea from the ...