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Organic letters

Intermolecular reactions of chlorohydrine anions: acetalization of carbonyl compounds under basic conditions

M Barbasiewicz, M Makosza

文献索引:Barbasiewicz, Michal; Makosza, Mieczyslaw Organic Letters, 2006 , vol. 8, # 17 p. 3745 - 3748

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被引用次数: 50

摘要

Nonenolizable aldehydes and ketones react with 2-chloroethanol and 3-chloropropanol under basic conditions (t-BuOK, DMF/THF) with formation of 2-substituted 1, 3-dioxolanes and 1, 3-dioxanes, respectively. Conversion of the two-step addition-alkylation process depends on the electrophilicity of the carbonyl group that governs the equilibrium of addition of chloroalkoxides. This method of protection of carbonyl groups in the form of cyclic ...

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