Formal Total Synthesis of the Algal Toxin (−)??Polycavernoside A

…, J Llaveria, A Yada, A Fürstner

文献索引：Brewitz, Lennart; Llaveria, Josep; Yada, Akira; Fuerstner, Alois Chemistry - A European Journal, 2013 , vol. 19, # 14 p. 4532 - 4537

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被引用次数: 42

摘要

Abstract A concise and largely catalysis-based approach to the potent algal toxin polycavernoside A (1) is described that intercepts a late-stage intermediate of a previous total synthesis; from there on, this challenging target can be reached in a small number of steps. Key to success was a sequence of a molybdenum-catalyzed ring-closing alkyne metathesis (RCAM) reaction to forge the macrocyclic frame, followed by a gold-catalyzed ...