Tetrahedron Letters

Catalyst-free, facile, and an efficient synthesis of α-aminonitriles employing Zn (CN) 2 as an ecofriendly cyanating agent

S Shah, B Singh

文献索引：Shah, Sakshi; Singh, Baldev Tetrahedron Letters, 2012 , vol. 53, # 2 p. 151 - 156

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被引用次数: 15

摘要

An efficient and eco-friendly method has been developed for the synthesis of α-aminonitriles via one-pot three-component condensation of carbonyl compounds, amines, and Zn (CN) 2 under mild conditions. This protocol has the features of use of inexpensive, ecofriendly readily available, effective cyanide source, high yield, and simple work-up procedure.