Synthesis of new polysubstituted piperazines and dihydro-2H-pyrazines by selective reduction of 2-oxo-piperazines

G Reginato, B Di Credico, D Andreotti, A Mingardi…

文献索引：Reginato, Gianna; Credico, Barbara Di; Andreotti, Daniele; Mingardi, Anna; Paio, Alfredo; Donati, Daniele; Pezzati, Bernardo; Mordini, Alessandro Tetrahedron Asymmetry, 2010 , vol. 21, # 2 p. 191 - 194

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被引用次数: 6

摘要

New enantiomerically enriched 1, 4, 5-piperazines and 1, 4, 5-dihydro-2H-pyrazines have been prepared by reduction of the corresponding 2-oxo-piperazines. Selective reduction can be achieved by careful control of the reaction conditions using LiAlH4. Notably the two ...