Synthetic communications

A Novel and Facile Method to Synthesize (R)??and (S)??2??methylpiperazine

B Liu, GY Xu, CH Yang, XH Wu…

文献索引：Liu, Bo; Xu, Guang-Yu; Yang, Chun-Hao; Wu, Xi-Han; Xie, Yu-Yuan Synthetic Communications, 2004 , vol. 34, # 22 p. 4111 - 4118

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被引用次数: 7

摘要

A concise and efficient synthesis of (R)?? and (S)??2??methylpiperazine in only five steps from (D)?? and (L)??alanine is described. The key step is reaction of benzylamine with a bifunctional molecule to build a six??membered ring. ... A concise and efficient synthesis of (R)?? and (S)??2??methylpiperazine in only five steps from (D)?? and (L)??alanine is described. The key step is reaction of benzylamine with a bifunctional molecule to build a six??membered ring.