A concise and efficient synthesis of (R)?? and (S)??2??methylpiperazine in only five steps from (D)?? and (L)??alanine is described. The key step is reaction of benzylamine with a bifunctional molecule to build a six??membered ring. ... A concise and efficient synthesis of (R)?? and (S)??2??methylpiperazine in only five steps from (D)?? and (L)??alanine is described. The key step is reaction of benzylamine with a bifunctional molecule to build a six??membered ring.
