Abstract Several 13-cis-retinamides were synthesized from 13-cis-retinoic acid via either 13- cis-retinoyl chloride or 13-cis-1-retinoylimidazole. All-trans-retinoylglycine was prepared from all-trans-retinoyl chloride and ethyl glycinate. Detailed procedures were developed for the preparation of other all-trans-retinamides on a large scale for studies of the chemoprevention of cancer.
![[4-[[(2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoyl]amino]phenyl] 2,2-dimethylpropanoate结构式](https://image.chemsrc.com/caspic/492/75664-77-6.png)
![(7cis,9cis,13cis)-15-[(3-Hydroxypropyl)amino]retinal结构式](https://image.chemsrc.com/caspic/220/75664-71-0.png)