Preparation of Benzoyloxy Benzophenone Derivatives and Their Inhibitory Effects of ICAM-1 Expression

EM Kwon, CG Kim, AR Goh, JS Park…

文献索引：Kwon, Eun Mi; Kim, Cheol Gi; Goh, Ah Ra; Park, Jinseu; Jun, Jong-Gab Bulletin of the Korean Chemical Society, 2012 , vol. 33, # 6 p. 1939 - 1944

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被引用次数: 4

摘要

Abstract Benzoyloxy benzophenone derivatives were prepared in 3 steps including DCC coupling, Fries rearrangement and esterification from benzoic acids in 24-89% total yields. Among the prepared 12 benzophenone analogues 1a-1l, the compound 1b having three chloro groups at the para position showed maximum inhibitory effects of ICAM-1 expression but, 1a which have no substituents at all showed no inhibitory activity. This study provides ...