C 19-Steroids as androgen receptor modulators: design, discovery, and structure-activity relationship of new steroidal androgen receptor antagonists

P Marwah, A Marwah, HA Lardy, H Miyamoto…

文献索引：Bioorganic and Medicinal Chemistry, , vol. 14, # 17 p. 5933 - 5947

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被引用次数: 19

摘要

... Bioorganic & Medicinal Chemistry. ... Androgen deprivation can be achieved either by suppressing the secretion of testicular androgens by means of surgical or medical castration, or by inhibiting the action of androgens using androgen antagonists such as hydroxyflutamide (HF ...