C 19-Steroids as androgen receptor modulators: design, discovery, and structure-activity relationship of new steroidal androgen receptor antagonists

P Marwah, A Marwah, HA Lardy, H Miyamoto…

Index: Bioorganic and Medicinal Chemistry, , vol. 14, # 17 p. 5933 - 5947

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Citation Number: 19

Abstract

... Bioorganic & Medicinal Chemistry. ... Androgen deprivation can be achieved either by suppressing the secretion of testicular androgens by means of surgical or medical castration, or by inhibiting the action of androgens using androgen antagonists such as hydroxyflutamide (HF ...