An Unusual (R)??Selective Epoxide Hydrolase with High Activity for Facile Preparation of Enantiopure Glycidyl Ethers

…, X Ju, XD Kong, J Pan, Y Tang, JH Xu

文献索引：Zhao, Jing; Chu, Yan-Yan; Li, Ai-Tao; Ju, Xin; Kong, Xu-Dong; Pan, Jiang; Tang, Yun; Xu, Jian-He Advanced Synthesis and Catalysis, 2011 , vol. 353, # 9 p. 1510 - 1518

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被引用次数: 23

摘要

Abstract A novel epoxide hydrolase (BMEH) with unusual (R)-enantioselectivity and very high activity was cloned from Bacillus megaterium ECU1001. Highest enantioselectivities (E> 200) were achieved in the bioresolution of ortho-substituted phenyl glycidyl ethers and para-nitrostyrene oxide. Worthy of note is that the substrate structure remarkably affected the enantioselectivities of the enzyme, as a reversed (S)-enantiopreference was unexpectedly ...