Application of Hansch's Model to Capsaicinoids and Capsinoids: A Study Using the Quantitative Structure− Activity Relationship. A Novel Method for the Synthesis of …

…, JMG Molinillo, RM Varela, M Palma…

文献索引：Barbero, Gerardo F.; Molinillo, Jose M. G.; Varela, Rosa M.; Palma, Miguel; MacIas, Francisco A.; Barroso, Carmelo G. Journal of Agricultural and Food Chemistry, 2010 , vol. 58, # 6 p. 3342 - 3349

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被引用次数: 25

摘要

We describe a synthetic approach for two families of compounds, the capsaicinoids and capsinoids, as part of a study of the quantitative relationship between structure and activity. A total of 14 capsaicinoids of increasing lateral chain lengths, from 2 to 16 carbon atoms, were synthesized. In addition, 14 capsinoids with identical lateral chains, as well as capsiate and dihydrocapsiate, have been synthesized, and a new method for the synthesis of these ...