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Solid Phase Synthesis of Diamino??Substituted Pyrimidines

…, D Barlocco, LF Raveglia

文献索引:Barillari, Caterina; Barlocco, Daniela; Raveglia, Luca F. European Journal of Organic Chemistry, 2001 , # 24 p. 4737 - 4741

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被引用次数: 8

摘要

Abstract 2, 4-and 4, 6-Diamino-substituted pyrimidines are known for their biological activity in many therapeutic areas. A novel solid-phase synthesis of this class of compounds by nucleophilic aromatic substitution has been set up and the reactivity of differently substituted solid-supported pyrimidines with properly selected amines has been studied. Using this methodology a small library of diamino-substituted pyrimidines has been prepared.