ANTIPYRETIC, ANTINOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF CERTAIN γ-OXOBUTANOIC ACID DERIVATIVES

…, KM Youssef, AAE Ahmed, HH Al-Zuhair

文献索引：Abouzid, Khaled A. M.; Youssef, Khairia M.; Ahmed, Amany A. E.; Al-Zuhair, Hanaa Hussain Medicinal Chemistry Research, 2005 , vol. 14, # 1 p. 26 - 39

全文：HTML全文

被引用次数: 4

摘要

Abstract Three chemical entities were synthesized as analogs of fenbufen as well as open ring analog of suldinac and celecoxib. The new compounds were evaluated for antipyretic, antinociceptive and anti-inflammatory activities. Among these compounds, 6-benzo [1, 3] dioxol-5-yl-4-oxo-hex-5-enoic acid (3) was the most active one.