Abstract Three chemical entities were synthesized as analogs of fenbufen as well as open ring analog of suldinac and celecoxib. The new compounds were evaluated for antipyretic, antinociceptive and anti-inflammatory activities. Among these compounds, 6-benzo [1, 3] dioxol-5-yl-4-oxo-hex-5-enoic acid (3) was the most active one.
![(Z)-6-benzo[1,3]dioxol-5-yl-4-oxo-hex-5-enoic acid Structure](https://image.chemsrc.com/caspic/209/69662-21-1.png)