Synthesis

Chemoselective reductive amination of aldehydes and ketones by dibutylchlorotin hydride-HMPA complex

T Suwa, E Sugiyama, I Shibata, A Baba

文献索引：Suwa, Toshihiro; Sugiyama, Erika; Shibata, Ikuya; Baba, Akio Synthesis, 2000 , # 6 p. 789 - 800

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被引用次数: 49

摘要

Abstract: Reductive amination of various aldehydes and ketones has been performed effectively by pentacoordinate chloro-substituted tin hydride complex, Bu2SnClH-HMPA. The tin reagent worked particularly well for the case using weakly basic aromatic amines as starting substrates. Stoichiometric amounts of a substrate and a reducing agent were adequate for the reaction. The Sn-Cl bond in the complex plays an important role for both ...