Practical synthesis of 5, 6, 7, 8-tetrahydro-4-methoxy-6-methyl-1, 3-dioxolo [4, 5-g] isoquinolin-5-ol (cotarnine)

T Shirasaka, Y Takuma, T Shimpuku…

文献索引：Shirasaka, Tadashi; Takuma, Yuki; Shimpuku, Tetsuro; Imaki, Naoshi Journal of Organic Chemistry, 1990 , vol. 55, # 12 p. 3767 - 3771

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被引用次数: 19

摘要

" The reaction was carried out using 3 mmol of lla.* The reaction intermediate (tR= 13.2 min) remained. CThe starting material lla remained. dN, was bubbled into the solution during the reaction with the addition of H, O to keep the reaction volume constant. mL/mmol8a) and allowed to stand at room temperature for 4 days according to Bobbitt's pr~ cedure.'~ Recrystallization from EtOH gave 9 in the low yield of 33% due to the difficulty of ...